Cytogenetic Analysis in Infertile Male Patients with Oligospermia and Azoospermia in the Southern Region of Iran, Shiraz

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چکیده

Infertility, considered as one of the main public health issues, affects about 10%-15% of the couples in reproductive age. Male factors are known to be responsible for 50% of all infertilities. It is well-established that the chromosomal abnormality is more prevalent in infertile men than in fertile men [1]. In developed countries, the incidence factor is considered to be less, when compared to underdeveloped countries [2]. Male factor infertility includes chromosome and gene abnormalities, hormonal problems, genital infections, chemical and physical agents, varicose, genito-urinary obstruction, testicular dysfunction, etc. In addition, genetic abnormalities are suspected to result in male infertilities in about one-third of the cases, referred to as idiopathic.

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منابع مشابه

O-1: Evaluation of Ethnic Patterns of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia/Severe Oligospermia Referred to Royan Institute

Background: Microdeletions of the long arm of the chromosome Y are the most common molecular genetic cause of severe infertility in men which affect three regions of AZFa, AZFb and AZFc (Azoospermia factor). These regions contain various genes involved in spermatogenesis. The effect of ethnicity on the patterns of Y chromosome microdeletions has not been extensively studied, particulary in Iran...

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Y Chromosome Microdeletions in Infertile Men from South West of Iran

Today, with advances in assisted reproductive techniques, many infertile couples are able to have children. However, there is always risk of passing genetic abnormalities associated with infertility from parents to children. Therefore, detection of microdeletions of Y chromosome in patients with spermatogenesis failure seems very important. The purpose of this study was to determine the frequen...

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بررسی حذف های کوچک کروموزوم Y در مردان نابارور مراجعه کننده به بیمارستان فاطمیه همدان با روش Multiplex PCR

Introduction & Objective: Male factor is the major cause of infertility in 20% of cases (WHO). There are known etiologies for 70% of cases .However, 30% of infertility cases are of idiopathic origin. The Y chromosome and micro deletion of the long arm of the Y chromosome (Yq) in three regions (AZFa, AZFb ,AZFc ) are associated with spermatogenic failure and is a major etiology for oligo and a...

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Frequency of Y Chromosome Microdeletions in Azoospermic and Oligospermic Iranian Infertile Men

Background and Aims: Azoospermia factor (AZF) region of the Y-chromosome has several genes which are responsible for normal spermatogenesis. Microdeletions of these genes are associated with azoospermia and oligospermia. These microdeletions are too small to be detected by karyotyping. They can be easily identified using polymerase chain reaction. The aim of this study is to determine the frequ...

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بررسی مولکولی حذف‌های کروموزوم Y در نواحی AZF بیماران مبتلا به آزواسپرمی و اولیگواسپرمی غیر انسدادی مراجعه‌کننده به مرکز ناباروری منتصریه مشهد

Background and Aim: The Y-chromosome azoospermic factor (AZF) regions consist of genes whose specific roles and functions in spermatogenesis and fertility have not been completely clarified. Hence, recognition of the association between AZF microdeletions and male infertility has suggestions for the diagnosis, treatment, and genetic counseling. The main objective of the present study was invest...

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تاریخ انتشار 2016